Zdravljenje intrahepatalnega holangiokarcinoma s stereotaktičnim obsevanjem Treatment of intrahepatic cholangiocarcinom with stereotactic body radiation therapy

case report

Abstract

V prispevku je opisan primer bolnice z lokalno napredovalim holangiokarcinomom intrahepatalnih žolčnih vodov, ki je redek malignom s svojevrstnim kliničnim potekom. Ob postavitvi diagnoze ima večina bolnikov napredovalo obliko bolezni in so posledično kandidati le za nekirurško zdravljenje – kemoterapijo, kombinacijo kemoterapije in radioterapije ali samo radioterapijo. Glavna omejitev pri zdravljenju z radioterapijo je doza, ki jo prejmejo jetra in priležni cevasti organi, zato se v zadnjem času čedalje bolj uveljavlja zdravljenje s stereotaktično radioterapijo, ki omogoča, da dovedemo visoko dozo na tumor ob tem, da ščitimo rizične organe. Raziskave, ki so bile objavljene v zadnjih letih, so pokazale dobre rezultate zdravljenja inoperabilne bolezni  z namenom poskusa zazdravitve bolezni in podaljšanja celokupnega preživetja.

Abstract (Eng)

A case report of a patient with loccally adanced intrahepatic cholangiocarcinom, which is a rare malignancy with a unique clinical course, is presented in this paper. Most patients with this type of cancer have advanced disease at the time of diagnosis and are candidates for non-surgical treatments – chemotherapy, radiotherapy or chemoradiotherapy. The main limiting factor with external beam radiotherapy is the dose that is delivered to the liver and adjacent radiosensitive organs. Particularly, due to its ability to deliver a high and focused dose, stereotactic body radiation therapy is a promising treatment technique. Studies published on this topic have shown promising results regarding treatment of patients with unresectable disease with the intent of extending the overall survivor.